Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphine's immunoregulatory actions are not shared by fentanyl

T V Bilfinger1, C Fimiani, G B Stefano

  • 1Department of Surgery, University Hospital and Medical Center, State University of New York at Stony Brook, 11794, USA. bilfinge@surg.som.sunysb.edu

International Journal of Cardiology
|August 1, 1998
PubMed
Summary

Fentanyl, a common anesthetic, offers pain relief but doesn't affect nitric oxide release or cell adhesion like morphine. This means it cannot reduce surgical inflammation, particularly during cardiopulmonary bypass.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut, Microbiome, and Brain Regulatory Axis: Relevance to Neurodegenerative and Psychiatric Disorders.

Cellular and molecular neurobiology·2018
Same author

Endogenous morphine: up-to-date review 2011.

Folia biologica·2012
Same author

Psychiatric implications of endogenous morphine: up-to-date review.

Folia biologica·2011
Same author

Morphine-mediated alteration of hypertension-related gene expression in human white blood cells and multilineage progenitor cells.

Journal of human hypertension·2010
Same author

Resection of giant right-sided thymoma using a lateral thoracotomy approach followed by median sternotomy for completion thymectomy.

The Thoracic and cardiovascular surgeon·2007
Same author

Cholinergic regulation of morphine release from human white blood cells: evidence for a novel nicotinic receptor via pharmacological and microarray analysis.

International journal of immunopathology and pharmacology·2007

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Immunology

Background:

  • Fentanyl is a widely used narcotic analgesic in anesthesia.
  • Morphine shares analgesic properties with fentanyl but differs in receptor binding and downstream effects.
  • Inflammatory responses during surgery, especially cardiopulmonary bypass, are a significant clinical concern.

Purpose of the Study:

  • To compare the effects of fentanyl and morphine on nitric oxide release and cell adhesion.
  • To investigate the impact of fentanyl on the inflammatory response.
  • To determine if fentanyl can downregulate inflammation associated with cardiopulmonary bypass.

Main Methods:

  • Amperometric measurement of nitric oxide release.
  • Assessment of cell adhesion.

Related Experiment Videos

  • Evaluation of inflammatory markers post-surgery.

    • Main Results:

    • Fentanyl does not bind to the mu3 receptor, unlike morphine.
    • Fentanyl did not influence nitric oxide release or cell adhesion.
    • Fentanyl lacks the ability to downregulate the inflammatory response.

    Conclusions:

    • Fentanyl's mechanism of action differs from morphine regarding mu3 receptor binding.
    • Fentanyl's inability to modulate nitric oxide and cell adhesion limits its anti-inflammatory potential.
    • Fentanyl may not be suitable for mitigating surgical inflammatory responses, particularly in cardiopulmonary bypass procedures.