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Diffusional permeability of rabbit mesothelium

L Zocchi1, A Raffaini, E Agostoni

  • 1Istituto di Fisiologia Umana I, Università di Milano, 20133 Milan, Italy.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 4, 1998
PubMed
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This study reveals that the rabbit pericardium

Area of Science:

  • Physiology
  • Biophysics
  • Membrane Transport

Background:

  • The pericardium, a serous membrane, plays a crucial role in protecting the heart.
  • Understanding its permeability is vital for studying drug delivery and physiological processes.
  • Previous studies may have overestimated permeability due to tissue preparation methods.

Purpose of the Study:

  • To accurately determine the diffusional permeability of rabbit pericardium to sucrose and Na+.
  • To investigate the influence of phospholipids on pericardial permeability.
  • To differentiate the permeability contributions of the mesothelium and underlying connective tissue.

Main Methods:

  • Ussing chamber experiments were used to measure permeability coefficients.
  • Radiolabeled sucrose and Na+ were employed to track diffusion across pericardial specimens.

Related Experiment Videos

  • Experiments were conducted with and without adsorbed phospholipids on the mesothelial surface.

    • Main Results:

    • Diffusional permeability (P) to sucrose (Psuc) was significantly lower in intact pericardium compared to previously reported values for stripped pleura.
    • Adsorbed phospholipids on the mesothelial surface reduced both Psuc and PNa+.
    • The mesothelium, not the connective tissue, was identified as the primary barrier to diffusion across the pericardium.

    Conclusions:

    • Tissue stripping likely damages mesothelium, leading to overestimated permeability in prior studies.
    • The mesothelial layer of the pericardium is the main determinant of its diffusional resistance.
    • Adsorbed phospholipids further modulate pericardial permeability, impacting transport across this barrier.