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Misty (m) affects growth traits

G E Truett1, R J Tempelman, J A Walker

  • 1Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.

The American Journal of Physiology
|August 5, 1998
PubMed
Summary
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The misty (m) coat color mutation significantly impacts mouse growth, affecting size and weight. This finding is crucial for accurately studying obesity (Leprdb) mutations linked to m.

Area of Science:

  • Genetics
  • Animal Models
  • Obesity Research

Background:

  • The misty (m) coat color mutation is often used as a marker for the diabetes (Leprdb) obesity mutation.
  • Previous studies assumed 'm' did not influence traits studied alongside 'Leprdb'.

Purpose of the Study:

  • To investigate the impact of the misty (m) coat color mutation on growth traits independently of the Leprdb mutation.
  • To determine if the 'm' mutation confounds the study of 'Leprdb' effects.

Main Methods:

  • Analysis of growth curves in mice segregating the 'm' mutation without the 'db' mutation.
  • Analysis of variance for traits including body length, weight, and inguinal adipose mass at 35 days of age.

Main Results:

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  • Mice with the m/m genotype were significantly smaller than M/M mice from the second week of life onwards.
  • At 35 days, m/m mice were 8% shorter, 15% lighter, and had 21% less inguinal fat compared to M/M mice.
  • The 'm' mutation demonstrably affects growth and adiposity.

    • Conclusions:

    • The misty (m) mutation has a significant effect on growth traits in mice.
    • Linkage between 'm' and 'Leprdb' confounds the interpretation of Leprdb genotype effects.
    • Direct assays for Leprdb genotype and removal of 'm' are recommended for accurate research.