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Updated: Aug 13, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
Published on: July 22, 2011
Major histocompatibility complex-based suppression: a mechanism for T-cell control
1Nuffield Department of Surgery, University of Oxford, UK.
Abstract:
The crucial cell for immune system control is the T-cell. Current theories for T-cell control lack a credible mechanism for active down-regulation, because any mechanism that actively switches off T-cells must be secure from duplication by invading organisms. This hypothesis presents a system for T-cell control which is secure because it requires recognition of the highly polymorphic molecules of the MHC by the T-cell receptor as the down-regulatory mechanism, thus using the MHC as a form of individual security code.
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