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Oligonucleotide libraries--variatio delectat

M Famulok¹, A Jenne

¹Institut für Biochemie, LMU München, Germany. Famulok@lmb.uni-muenchen.de

Current Opinion in Chemical Biology

|August 6, 1998

Summary

This summary is machine-generated.

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In vitro selection generates aptamers (RNA or DNA molecules) that bind targets and ribozymes (catalytic nucleic acids). These tools are valuable for molecular biology, diagnostics, and medicine.

Area of Science:

Biochemistry
Molecular Biology
Genetics

Background:

Combinatorial nucleic acid libraries can be selected in vitro.
This selection process yields molecules with specific functions.

Purpose of the Study:

To describe the current state of aptamer and ribozyme technology.
To highlight their utility in various scientific fields.

Main Methods:

In vitro selection of combinatorial nucleic acid libraries.
Identification of RNA and DNA molecules with specific binding or catalytic properties.

Main Results:

Successful generation of specific target-binding aptamers (RNA, ssDNA, modified RNA, modified DNA).
Discovery of novel catalytic nucleic acids (ribozymes).

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Conclusions:

Aptamer and ribozyme technologies are established methods.
These technologies provide essential tools for molecular biology, diagnostics, molecular medicine, and bio-organic chemistry.