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[Chinese Human Genome Project--opportunity and challenge]
1Shanghai Human Genome Center, Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P. R. China. zchen@ms.stn.sh.cn
Summary
The Chinese Human Genome Project has advanced genome resource conservation, technological development, and disease-gene cloning. Future work includes expanding genetic resources, morbid and functional genomics, and ethical considerations.
Area of Science:
- Human Genetics
- Genomics
- Molecular Biology
Context:
- The Chinese Human Genome Project (HGP) commenced in 1993.
- Significant advancements have been made in genome resource conservation, technological development, and disease-related gene cloning.
- A skilled research team and dedicated genome study centers have been established.
Purpose:
- To expand genetic material conservation, encompassing DNA samples and cell lines.
- To develop morbid genomics through epidemiological surveys and genetic resource banking.
- To advance functional genomics, including bioinformatics and gene expression studies.
- To investigate ethical, legal, and social implications of human genome science.
Summary:
- Progress includes genome resource conservation, genetic polymorphism studies, and technological system development.
- Cloning of disease-related genes and a large number of expressed sequence tags (ESTs) have been achieved.
- Future phases focus on expanding genetic material, developing morbid and functional genomics, and addressing ethical, legal, and social issues.
Impact:
- Formation of a qualified research team and establishment of genome study centers in China.
- Laying the groundwork for future breakthroughs in understanding and treating genetic diseases.
- Enhancing national capacity in cutting-edge human genome research and its societal implications.