An immuno-biological test of species specificity in a low-molecular organic extract (<10,000 D)

A pharmacological formulation derived from bovine blood was studied for species-specific substances, the problem being the low-molecular weight of its components. A detection of the species specificity for bovines was possible exclusively by the use of monovalent bovine-specific blood group sera. All other sera showed cross-reactions. Inhibition tests and blood-group-specific bovine test sera enabled us to identify the species specificity of bovines in the drug concentrate at dilutions up to 1/1,000 which are used as the basis for the production of the medication. The requirement of the German authorities (BGA) to examine the specificity of the identity in the medication can therefore be met by this immunobiological method.