Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Septicemia and systemic inflammatory response]

P Pierucci1, M Marroni, R Papili

  • 1Istituto di Clinica delle Malattie Infettive, Università, Perugia.

Recenti Progressi in Medicina
|August 6, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early pronation, protective lung ventilation and use of awake-prone-HFNO therapy after extubation in near-fatal drowning.

Pulmonology·2023
Same author

Tele-consultation: A new promised land?

Pulmonology·2022
Same author

The Anti-Leukemia Effect of Ascorbic Acid: From the Pro-Oxidant Potential to the Epigenetic Role in Acute Myeloid Leukemia.

Frontiers in cell and developmental biology·2022
Same author

The eye may be the spy of injury related to NIV interface and prone positioning.

Pulmonology·2022
Same author

Daytime non-invasive ventilatory support via intermittent abdominal pressure for a patient with Pompe disease.

Pulmonology·2020
Same author

Effects of antiretroviral therapy on proprotein convertase subtilisin/kexin 9: focus on lipids, inflammation and immunovirological parameters.

HIV medicine·2020
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
See all related articles

Severe systemic inflammatory response syndrome (SIRS) in patients with endocarditis or septicemia significantly increases mortality. Differentiating between infection response and persistent bacteremia is crucial for accurate diagnosis and treatment outcomes.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Pathophysiology

Context:

  • Endocarditis and septicemia are serious infections with potential systemic complications.
  • Systemic Inflammatory Response Syndrome (SIRS) is a complex host response to infection.
  • The terminology surrounding sepsis and its related syndromes has evolved and can be ambiguous.

Purpose:

  • To investigate the relationship between endocarditis/septicemia and the development of SIRS, septic shock, and Multiple Organ Dysfunction Syndrome (MODS).
  • To analyze mortality rates in HIV-negative patients with endocarditis/septicemia based on the presence and severity of SIRS.
  • To clarify the definition and clinical utility of SIRS in the context of severe infections.

Summary:

  • A retrospective analysis of 196 HIV-negative patients with endocarditis/septicemia was conducted.

Related Experiment Videos

  • Patients with endocarditis without severe SIRS/septic shock had no deaths, while those with severe SIRS/septic shock had 3 deaths (P=0.052).
  • Septicemia patients with severe SIRS/septic shock exhibited a 12.3% mortality rate, with higher mortality in septic shock (16.6%) compared to severe SIRS (11.4%) (P=0.003).

    • Impact:

    • The findings support the continued justification of the historical definition of septicemia as persistent bacteremia.
    • "Infective SIRS" and "severe infective SIRS" can accurately describe host responses to infection.
    • Excessive or "severe infective SIRS" is linked to increased risk of septic shock, organ failure, and mortality, highlighting the importance of precise diagnostic terminology.