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Related Experiment Videos

[Stress and immunoallergy]

J Chihara1

  • 1Department of Clinical and Laboratory Medicine, Akita University School of Medicine.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|August 6, 1998
PubMed
Summary
This summary is machine-generated.

Stress may worsen allergic reactions like asthma by increasing adhesion molecules. This study shows stress influences inflammatory cell adhesion, potentially accelerating allergic responses.

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Area of Science:

  • Immunology
  • Psychoneuroimmunology
  • Cell Biology

Context:

  • Adhesion molecules, particularly intercellular adhesion molecule-1 (ICAM-1), are crucial in inflammatory responses seen in allergic conditions like bronchial asthma.
  • Previous research indicated hyperresponsiveness in guinea pigs subjected to restriction stress.
  • The role of stress in modulating adhesion molecule expression on inflammatory and endothelial cells requires further elucidation.

Purpose:

  • To investigate the involvement of stress in the expression of adhesion molecules on inflammatory cells and endothelial cells (EC).
  • To determine if stress influences leukocyte adherence and eosinophil recruitment in a guinea pig model.

Summary:

  • Interleukin-1 (IL-1), platelet-activating factor (PAF), and platelet factor 4 (PF4) induced ICAM-1 expression on human EC.

Related Experiment Videos

  • Electric shock stress in guinea pigs augmented leukocyte adherence to plasma-coated glass and autologous bronchial ciliary cells.
  • Stress exposure led to increased eosinophil counts and percentages within adherent leukocytes.

    • Impact:

    • Findings suggest stress can enhance adhesion molecule expression, potentially accelerating allergic inflammatory conditions such as bronchial asthma.
    • This research highlights a link between psychoneuroimmunology and allergic disease pathogenesis.
    • Understanding stress-induced inflammatory mechanisms may offer new therapeutic targets for allergic diseases.