[Effects of endolymphatic lymph stimulation on draining and transporting function of the lymphatic system in...

Bacterial aggression and tissue destruction during experimental peritonitis cause progressive disorders of blood and lymph microcirculation, paralleled by increase of the coagulation potential of the blood and lymph, activation (during the first 12 hr) of the drainage function of the lymph system, followed in 24 h by a drop of lymph flow and its complete blocking in 48-72 h. This is caused by disseminated microhemo- and lymphothrombosis with decompensation of the drainage and transporting functions of the lymph system during this period of the disease. Lymphogenic effect of endolymphatic stimulation by drugs in experimental peritonitis is notably (by 1.8-4.5 times) higher than the effect of routine lymph stimulation with the same drugs and their combinations.