Interstitial laser coagulation: evaluation of the effect of normal liver blood perfusion and the application mode on lesion size
Related Experiment Video
Updated: Oct 28, 2026
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
D Albrecht1, C T Germer, C Isbert
1Department of Surgery, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
Background And Objective:
The effect of temporarily interrupted hepatic blood flow and multiple-fiber application on necrosis volume in interstitial laser coagulation (ILC) was investigated.
Study Design/Materials And Methods:
Single- and multiple-fiber ILC were performed in porcine livers with normal as well as interrupted perfusion. Temperatures were determined. Lesions were measured and studied by light microscopy 4 hours post-treatment.
Results:
ILC with multiple-fiber application led to significantly greater individual lesion volumes (3.7 +/- 0.5 cm3) than single-fiber application (2.5 +/- 0.5 cm3) (P < .01). The interruption of hepatic perfusion led to a significant increase in lesion volume with single- (7.5 +/- 1.0 cm3) as well as multiple-fiber application (12.6 +/- 2.2 cm3) (P < .01). Superposition of the lesions in the multiple-fiber application mode was only determined with interrupted perfusion (total volume: 50.3 +/- 6.6 cm3).
Conclusion:
Interruption of hepatic perfusion increases lesion volumes significantly. ILC for treating liver tumors should preferably be performed by application routes that permit temporary interruption of hepatic perfusion.
More Related Videos
05:56Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
Published on: January 9, 2019
06:58Microvascular Perfusion Monitored by Laser Speckle Contrast Imaging during Renal Ischemia-Reperfusion Injury in Mice
Published on: February 27, 2026