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Related Experiment Videos

LDL oxidation: therapeutic perspectives

F R Heller1, O Descamps, J C Hondekijn

  • 1Department of Internal Medicine, Hopital de Jolimont, Belgium.

Atherosclerosis
|August 7, 1998
PubMed
Summary

Antioxidants like vitamin C and E may help prevent atherosclerosis by inhibiting lipid peroxidation. Dietary antioxidants and certain drugs show potential, but clinical relevance requires further investigation, especially when cholesterol is high.

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Area of Science:

  • Cardiovascular Science
  • Nutritional Biochemistry
  • Pharmacology

Background:

  • Lipid peroxidation is a key factor in atherosclerosis development.
  • Antioxidant compounds, both endogenous and exogenous, may offer protective effects.
  • Ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) are primary hydrophilic and lipophilic antioxidants, respectively.

Purpose of the Study:

  • To review the role of antioxidants in preventing atherosclerosis.
  • To explore the mechanisms and efficacy of various antioxidant compounds.
  • To assess the clinical relevance of antioxidant properties in cardiovascular disease prevention.

Main Methods:

  • Literature review of animal and human studies on antioxidants and atherosclerosis.
  • Examination of in vitro and in vivo data on antioxidant compounds (e.g., vitamins C and E, flavonoids, probucol).
  • Analysis of studies investigating the impact of interventions targeting LDL oxidative susceptibility.

Main Results:

  • Ascorbic acid and alpha-tocopherol show potential preventive effects against coronary heart disease.
  • Plant phenols, flavonoids (e.g., in red wine, Mediterranean diet), and specific antioxidants (probucol, butylated hydroxytoluene) can inhibit atherosclerotic lesions in animal models.
  • Some drugs exhibit in vitro antioxidant effects, but their clinical significance is largely unknown.
  • Interventions reducing LDL oxidative susceptibility did not attenuate atherogenesis in the presence of high cholesterol.

Conclusions:

  • Antioxidants play a significant role in the pathogenesis and potential prevention of atherosclerosis.
  • Dietary and pharmacological antioxidants warrant further investigation for cardiovascular health.
  • The efficacy of antioxidants in preventing atherosclerosis is complex and may be limited by underlying high cholesterol levels.

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