Related Experiment Videos
Homology modeling, model and software evaluation: three related resources
R Rodriguez1, G Chinea, N Lopez
1Center for Genetic Engineering and Biotechnology, Havana, Cuba and 2BIOcomputing, EMBL, Heidelberg, Germany.
Bioinformatics (Oxford, England)
|August 8, 1998
Summary
Homology modeling generates protein structures from sequences. Three new servers provide tools for creating protein models and evaluating their quality, aiding researchers in structural biology.
Area of Science:
- Structural biology
- Computational biology
- Bioinformatics
Background:
- Genome projects accelerate protein sequence generation, outpacing experimental structure determination (NMR, X-ray crystallography).
- Homology modeling is increasingly vital for obtaining protein 3D coordinates.
- Novice users require support in assessing the quality of protein models.
Purpose of the Study:
- To provide accessible tools for homology modeling and model quality assessment.
- To offer a means for evaluating the performance of protein modeling programs.
Main Methods:
- Development and deployment of three distinct web servers: a homology modeling server, a model quality evaluation server, and a program quality assessment server.
- These servers are accessible via a web interface.
Main Results:
- Three functional servers are now available to the scientific community.
- The servers facilitate protein model generation, quality evaluation, and implicit assessment of modeling program performance.
- The tools are freely accessible online.
Conclusions:
- The developed servers address the growing need for reliable protein structure modeling and quality assessment.
- These resources support researchers in structural biology and computational chemistry.
- The availability of these tools enhances the utility of homology modeling in biological research.