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Btk function in B cell development and response

A B Satterthwaite1, Z Li, O N Witte

  • 1Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095-1662, USA.

Seminars in Immunology
|August 8, 1998
PubMed

Mutations in Bruton's tyrosine kinase (Btk) result in the B cell immunodeficiencies XLA in humans and Xid in mice. Both the maintenance of peripheral B cell numbers and their response to B cell antigen receptor (BCR) crosslinking depend on Btk. Btk integrates signals from multiple cell surface receptors, including BCR and G-protein coupled receptors. These Btk dependent signals control B cell proliferation and survival by mediating Ca2+ flux, activating JNK and p38 and inducing cell cycle regulatory genes.

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