Related Experiment Video
Updated: Aug 18, 2026
Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
Published on: April 7, 2023
Efficacy of treatment for unexplained infertility
D S Guzick1, M W Sullivan, G D Adamson
1University of Rochester, New York, USA.
Objective:
To analyze the efficacy and cost-effectiveness of alternative treatments for unexplained infertility.
Design:
Retrospective analysis of 45 published reports.
Setting:
Clinical practices.
Patient(S):
Couples who met criteria for unexplained infertility. Women with Stage I or Stage II endometriosis were included.
Intervention(S):
Observation; clomiphene citrate (CC); gonadotropins (hMG); IUI; and GIFT and IVF.
Main Outcome Measure(S):
Clinical pregnancy rate.
Result(S):
Combined pregnancy rates per initiated cycle, adjusted for study quality, were as follows: no treatment = 1.3%-4.1%; IUI = 3.8%; CC = 5.6%; CC + IUI = 8.3%; hMG = 7.7%; hMG + IUI = 17.1%; IVF = 20.7%; GIFT = 27.0%. The estimated cost per pregnancy was $10,000 for CC + IUI, $17,000 for hMG + IUI, and $50,000 for IVF.
Conclusion(S):
Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. If this treatment fails, hMG + IUI and assisted reproduction are efficacious therapeutic options.
More Related Videos
04:22Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
08:29Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation Failure
Published on: October 25, 2024
Related Concept Videos
01:41Spermatogenesis
01:24In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
01:23Infertility in Males
01:28Infertility in Females
Endometriosis, a condition characterized by abnormal growth of endometrial...