Malonyl-CoA--regulator of fatty acid oxidation in muscle during exercise
1Department of Zoology, Brigham Young University, Provo, Utah, USA.
Exercise and Sport Sciences Reviews
|August 11, 1998
Abstract:
As muscle goes from a resting state to exercise, the following sequence of events occurs (Figure 5.5): (1) The rise in AMP accompanying contraction allosterically activates AMPK and an AMPK kinase; (2) The activated AMPK kinase phosphorylates and further activates AMPK; (3) The activated AMPK phosphorylates and inactivates ACC; and (4) The consequent decline in malonyl-CoA (product of ACC reaction) relieves inhibition of CPT-1 and allows an increased rate of fatty acid oxidation when fatty acids become available.
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