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Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity
1Department of Chemistry, Indian Institute of Technology, Bombay, Powai, India. retinal@ether.chem.iitb.ernet.in
Biophysical Chemistry
|August 11, 1998
Abstract:
Absorption and fluorescence studies of retinol (vitamin A alcohol) and retinol palmitate (vitamin A palmitate) intercalated in phosphatidylcholine (PC) liposomes show that these compounds are bound to the lipid bilayer. It is further found that retinol binds liposomes with greater affinity as compared to retinol palmitate. In addition, the delivery of liposome-incorporated retinoids to the blood has also been studied and it is found that these systems reduce blood viscosity and cause less lysis of red blood cells than retinoid compounds not complexed in liposomes.