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Torsemide inhibits aldosterone secretion in vitro
T L Goodfriend1, D L Ball, W Oelkers
1William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA. tgoodfri@facstaff.wisc.edu
Life Sciences
|August 11, 1998
Abstract:
Torsemide inhibited aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. Inhibitory concentrations for adrenal cells (micromolar) were comparable with those reported to inhibit ion transport in isolated renal tubules. Inhibition of aldosterone secretion could reduce kaliuresis, and that may explain why torsemide causes less kaliuresis than other diuretics.