[Host-virus relationship during experimental spring viremia in carp]

Area of Science:

• Aquatic animal immunology
• Virology
• Fish health management

Context:

• Spring Viremia of Carp (SVC) is a significant viral disease affecting carp populations worldwide.
• Understanding the immune response in carp is crucial for developing effective disease control strategies.
• This study investigates the innate and adaptive immune responses in young carps to SVC virus infection.

Purpose:

• To determine the kinetics and intensity of interferon and neutralizing antibody production in carps following intraperitoneal injection of Spring Viremia of Carp virus.
• To evaluate the influence of different virus doses on the immune response.
• To assess the duration of antibody presence post-infection.

Summary:

• One-summer-old, virus-free carps were injected intraperitoneally with varying doses (10^5, 10^6, 10^7 pfu/fish) of Spring Viremia of Carp virus and stored at +20°C.
• Interferon production and neutralizing antibodies were measured to assess the immune response.
• Maximum interferon production and intensity were observed with the highest virus dose. Neutralizing antibodies were detected in most fish 2.5 months post-infection.

Impact:

• Provides insights into the immune mechanisms of carp against Spring Viremia of Carp virus.
• Informs potential vaccination strategies and disease management practices for carp aquaculture.
• Highlights the dose-dependent nature of the immune response to SVC virus in carps.