Related Experiment Videos
Gastric retentive drug-delivery systems
1Purdue University, School of Pharmacy, West Lafayette, IN 47907, USA. esp@omni.cc.purdue.edu
Critical Reviews in Therapeutic Drug Carrier Systems
|August 12, 1998
Summary
Developing long-term oral controlled-release dosage forms is challenging due to gastrointestinal transit. This study reviews six systems designed to extend gastric residence time and discusses future development needs.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Gastrointestinal (GI) transit limits oral controlled-release dosage form efficacy.
- Extending gastric residence time is crucial for sustained drug delivery.
Purpose of the Study:
- To review existing approaches for prolonging gastric residence time.
- To discuss necessary improvements for future oral controlled-release dosage forms.
Main Methods:
- Review of six common gastric residence time extending systems.
- Analysis of underlying GI physiology relevant to dosage form design.
Main Results:
- Six systems are detailed: floating, high-density, mucoadhesive, magnetic, unfoldable/extendible/swellable, and superporous hydrogels.
- Each system's concept and limitations are examined.
Conclusions:
- Further research is needed to optimize these systems for long-term oral delivery.
- Understanding GI physiology is key to advancing controlled-release technologies.