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Multiple schwannomas in the peripheral nerves

A Ogose1, T Hotta, T Morita

  • 1Niigata Cancer Centre Hospital and Niigata University, Japan.

The Journal of Bone and Joint Surgery. British Volume
|August 12, 1998
PubMed
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Multiple schwannomas can occur without neurofibromatosis. This review of 12 patients highlights diagnostic challenges and the low risk of malignant transformation in these peripheral nerve tumors.

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Multiple peripheral nerve tumors are commonly associated with neurofibromatosis type 1 or 2.
  • However, multiple schwannomas can manifest independently of neurofibromatosis.
  • This condition can be misdiagnosed as neurofibromatosis, leading to potential overtreatment.

Purpose of the Study:

  • To review cases of multiple schwannomas without neurofibromatosis.
  • To analyze clinical presentation, diagnostic challenges, and outcomes.
  • To clarify the risk of malignant transformation in these tumors.

Main Methods:

  • Retrospective review of 12 patients with multiple peripheral schwannomas.
  • Assessment of clinical data, including tumor size, location, and patient history.

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  • Histological diagnosis and follow-up for malignant changes.

    • Main Results:

    • None of the 12 patients met the diagnostic criteria for neurofibromatosis.
    • Tumor sizes ranged from 45 to 250 mm.
    • Some patients had additional spinal or intracranial lesions, café-au-lait spots, or a family history.
    • Malignant transformation was rare.

    Conclusions:

    • Multiple schwannomas can occur in the absence of neurofibromatosis.
    • Diagnostic confusion with neurofibromatosis and tumor size can lead to overtreatment.
    • Malignant change in multiple schwannomas is infrequent.