Riboflavin deficiency in children with diabetes mellitus
Acta Diabetologica Latina
|January 1, 1976
Summary
Children with insulin-dependent diabetes show a significantly higher prevalence of riboflavin deficiency compared to healthy children. Daily oral riboflavin supplementation effectively corrected this deficiency, normalizing enzyme activity.
Area of Science:
- Biochemistry
- Pediatrics
- Nutritional Science
Background:
- Insulin-dependent diabetes mellitus (IDDM) is a chronic metabolic disorder affecting children.
- Riboflavin (vitamin B2) is essential for cellular metabolism and antioxidant defense.
- Erythrocyte glutathione reductase activity coefficient (AC) is a key indicator of riboflavin status.
Purpose of the Study:
- To investigate the prevalence of riboflavin deficiency in children with IDDM.
- To compare riboflavin status between diabetic and non-diabetic children.
- To assess the efficacy of riboflavin supplementation in correcting deficiency.
Main Methods:
- Studied 24 children with IDDM and 114 healthy controls, aged 6-16 years.
- Measured erythrocyte glutathione reductase activity to determine the activity coefficient (AC).
- Assessed the impact of daily oral riboflavin supplementation on AC values.
Main Results:
- Diabetic children exhibited a 4-fold greater prevalence of riboflavin deficiency compared to controls.
- All measured activity coefficient (AC) values in deficient children normalized after riboflavin supplementation.
- No vitamin supplementation was administered prior to the study.
Conclusions:
- Children with insulin-dependent diabetes are at a higher risk for riboflavin deficiency.
- Riboflavin deficiency in these children is readily correctable with oral supplementation.
- Monitoring and addressing riboflavin status is important in pediatric diabetes management.
More Related Videos
Related Concept Videos
01:22Diabetes Mellitus: Overview and Type I Subtype
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
01:12Type I Diabetes I: Introduction
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
01:26Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
01:19Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
01:22Complications of Diabetes Mellitus
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...