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Related Experiment Videos

Comparison between ketotifen and DSCG in bronchial challenge

R Pauwels, H Lamont, M Van Der Straeten

    Clinical Allergy
    |May 1, 1978
    PubMed
    Summary

    Both oral ketotifen and inhaled DSCG effectively prevent allergen-induced bronchoconstriction. This 3-day treatment notably reduced immediate allergic airway reactions, with similar efficacy for both drugs.

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    Area of Science:

    • Allergy and Immunology
    • Pulmonary Medicine
    • Pharmacology

    Background:

    • Allergen-induced bronchoconstriction is a key feature of asthma.
    • Effective management strategies are crucial for improving patient outcomes.
    • Mast cell stabilizers and antihistamines are common therapeutic approaches.

    Purpose of the Study:

    • To compare the efficacy of oral ketotifen and inhaled disodium cromoglycate (DSCG) in preventing allergen-induced bronchoconstriction.
    • To evaluate the impact of both drugs on immediate and late asthmatic reactions.

    Main Methods:

    • A double-blind, cross-over study design was employed.
    • Participants received either oral ketotifen (1 mg) or inhaled DSCG (20 mg) four times daily for three days.
    • Bronchial challenge tests were used to assess allergen-induced reactions.

    Main Results:

    • Both ketotifen and DSCG demonstrated a comparable protective effect against allergen-induced bronchoconstriction.
    • A significant inhibition of immediate bronchial reactions was observed with both treatments.
    • Late asthmatic reactions were inhibited in 2 out of 3 patients by both ketotifen and DSCG.

    Conclusions:

    • Oral ketotifen and inhaled DSCG offer similar protective benefits against allergen-induced bronchoconstriction.
    • Both medications are effective in mitigating immediate allergic airway responses.
    • Further research may explore long-term efficacy and patient-reported outcomes.

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