Antiviral treatment of diseases in pediatric dermatology

Z Trizna1, S K Tyring

  • 1Department of Dermatology, University of Texas Medical Branch at Galveston, USA.

Dermatologic Clinics
|August 15, 1998
PubMed

Insights

This review covers pediatric skin conditions like herpes simplex virus, varicella-zoster virus, human papillomavirus, and molluscum contagiosum, focusing on new treatments and prevention strategies.

Area of Science:

  • Dermatology
  • Pediatrics
  • Virology

Background:

  • Pediatric dermatologic conditions require targeted therapeutic and prophylactic interventions.
  • Viral skin infections are common in children and necessitate effective management strategies.

Purpose of the Study:

  • To review pediatric dermatologic diseases with specific therapies and/or prophylactic measures.
  • To highlight recent advances in the treatment and prevention of common viral skin infections in children.

Main Methods:

  • Literature review of pediatric dermatologic diseases.
  • Focus on viral infections including herpes simplex virus, varicella-zoster virus, human papillomavirus, and molluscum contagiosum.
  • Emphasis on recent therapeutic and prophylactic advancements.

Main Results:

  • Identification of key pediatric dermatologic conditions with specific treatment protocols.
  • Summary of current and emerging therapies for viral skin infections.
  • Overview of prophylactic measures to prevent the spread and recurrence of these infections.

Conclusions:

  • Effective management of pediatric viral skin infections relies on specific therapies and prophylaxis.
  • Recent advances offer improved treatment options and prevention strategies for conditions like herpes simplex virus, varicella-zoster virus, human papillomavirus, and molluscum contagiosum.
  • Continued research is vital for further advancements in pediatric dermatology.

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...