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Updated: Aug 10, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
A historical perspective on gestational diabetes
1Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, Northern Ireland, U.K.
Extreme fetal macrosomia occurred in the first recorded case of diabetes in pregnancy in 1823. The belief that the diabetic condition was in some way a symptom of the pregnancy, which dates to that first report, has led to the more recent concept of gestational diabetes. Lesser degrees of maternal hyperglycemia were also recognized to be a risk to the baby, and early studies of carbohydrate intolerance in pregnancy in Boston and Los Angeles have set the stage for the worldwide interest in this maternal/fetal interaction.
Extreme fetal macrosomia occurred in the first recorded case of diabetes in pregnancy in 1823. The belief that the diabetic condition was in some way a symptom of the pregnancy, which dates to that first report, has led to the more recent concept of gestational diabetes. Lesser degrees of maternal hyperglycemia were also recognized to be a risk to the baby, and early studies of carbohydrate intolerance in pregnancy in Boston and Los Angeles have set the stage for the worldwide interest in this maternal/fetal interaction.
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