Drug therapy for atrial fibrillation--interactions with interventional therapy and implications for local drug...

Multiple therapeutic alternatives, both pharmacological and non-pharmacological, are under active investigation for the treatment of atrial fibrillation. Although many promising approaches are being investigated, there is as yet no universally accepted therapy, nor is there likely to be in the foreseeable future. It is possible that, since no one therapeutic intervention is ideal, a combination of pharmacological and non-pharmacological approaches may succeed in patients in whom neither therapy alone would be effective. In this paper, we explore interactions between devices and antiarrhythmic drugs, as well as novel methods of delivering anti-arrhythmic drug therapy.