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Striated membranous structures in human hearts. An ultrastructural study

V G Rentería, V J Ferrans, M Jones

    The American Journal of Pathology
    |October 1, 1976
    PubMed
    Summary

    Striated membranous structures (SMS) were identified in the extracellular locations of heart tissues in patients with valvular prolapse and congenital heart disease. These structures may originate from basement membrane components like Type IV collagen.

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    Area of Science:

    • Cardiovascular Pathology
    • Connective Tissue Biology

    Background:

    • Striated membranous structures (SMS) have been previously observed in renal and ocular tissues.
    • The presence and significance of SMS in cardiac tissues remain less understood.

    Observation:

    • SMS were identified in the mitral and tricuspid valves of patients with mitral valvular prolapse.
    • These structures were also found in the mitral valve and femoral artery of a patient with Marfan's syndrome and prolapsed mitral valve.
    • SMS were present in the myocardium and thickened endocardium of patients with congenital heart disease and right ventricular outflow obstruction.

    Findings:

    • The identified SMS varied in thickness (130-220 Å) and exhibited periodic substructure.
    • A majority of SMS showed thicknesses around 200 Å with distinct light and dark bands (100-160 Å periodicity).

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  • These structures were associated with thickened basement membranes, elastic fibers, and elastogenesis-related bodies.

    • Implications:

    • The findings suggest SMS may arise from an atypical arrangement of basement membrane components, potentially Type IV collagen.
    • This discovery expands the known locations and associations of SMS within cardiovascular tissues.
    • Further research is warranted to elucidate the precise role and formation mechanism of SMS in cardiac pathology.