Related Experiment Video
Updated: Aug 9, 2026

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
Published on: August 1, 2013
Infectious bursal disease and hemorrhagic enteritis
1Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Wooster 44691, USA. saif.1@osu.edu
Abstract:
Infectious bursal disease (IBD) of chickens and hemorrhagic enteritis (HE) of turkeys are caused by infectious bursal disease virus (IBDV) and hemorrhagic enteritis virus (HEV), respectively. Both diseases have common features, including an acute stage followed by immunosuppression, resulting in lowered resistance to a variety of infectious agents and poor response to commonly used vaccines. The IBDV and HEV infections are widespread in commercial chicken and turkey flocks, respectively. The acute stage of the disease, the immunosuppression that follows, and the widespread distribution of both diseases, are major factors contributing to the economic significance of both diseases. The mechanism of immunosuppression for both infections has similarities, both affect lymphocytes and macrophages, and both are lymphocidal. In this report, an overview of both diseases with emphasis on some of the recent findings will be presented. There has been greater research activity on IBD than on HE, reflecting the relative economic importance of the species affected and the recent changes in the antigenic make up and pathogenicity of the IBDV.
Related Concept Videos
Viral Recombination
Bacterial Gastroenteritis
Viral Meningitis
Poliomyelitis
Arboviral Encephalitis
Viral Hepatitis I: Introduction

