Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung function changes in smokers with normal conventional spirometry

M Marco, A Minette

    The American Review of Respiratory Disease
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction: Effectiveness of autologous mononuclear cells as adjuvant therapy in patients with ischaemic diabetic foot ulcers receiving indirect lower limb revascularization.

    Acta diabetologica·2024
    Same author

    Effectiveness of autologous mononuclear cells as adjuvant therapy in patients with ischaemic diabetic foot ulcers receiving indirect lower limb revascularization.

    Acta diabetologica·2024
    Same author

    Experimental and numerical analysis of the influence of intramedullary nail position on the cut-out phenomenon.

    Computer methods and programs in biomedicine·2023
    Same author

    Experimental validation of finite elements model in hip fracture and its clinical applicability.

    Revista espanola de cirugia ortopedica y traumatologia (English ed.)·2018
    Same author

    Bacteriocin biosynthesis contributes to the anti-inflammatory capacities of probiotic Lactobacillus plantarum.

    Beneficial microbes·2017
    Same author

    Long-Term Adherence to IFN Beta-1a Treatment when Using RebiSmart® Device in Patients with Relapsing-Remitting Multiple Sclerosis.

    PloS one·2016

    The single-breath nitrogen closing volume test detects more subtle lung function changes in smokers than standard spirometry. This test is crucial for early detection of obstructive lung disease in smokers.

    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology
    • Diagnostic Imaging

    Background:

    • Early detection of lung abnormalities in smokers is critical for preventing disease progression.
    • Conventional spirometry indices like 1-second forced expiratory volume (FEV1) may not identify subtle lung function changes.
    • Evaluating alternative lung function tests for improved sensitivity in smokers is necessary.

    Purpose of the Study:

    • To compare the ability of various lung function tests to detect early abnormalities in smokers.
    • To assess the effectiveness of novel spirometry indices against conventional measures.
    • To identify the most sensitive test for detecting subtle lung function impairments in smokers.

    Main Methods:

    • Established reference standards using healthy non-smokers for multiple lung function tests.

    Related Experiment Videos

  • Tested 80 male smokers using: 1-sec forced expiratory volume, vital capacity, end-tidal spirometry, forced mid- and end-expiratory flows, single-breath diffusing capacity, static lung volumes, and single-breath N2 closing volume.
  • Analyzed the sensitivity of each test in detecting abnormalities, particularly in smokers with normal conventional spirometry.

    • Main Results:

    • Forced mid- and end-expiratory flows did not improve upon conventional indices (FEV1, FEV1/VC ratio) for detecting obstructive lung disease.
    • In smokers with normal conventional spirometry, end-tidal spirometry, diffusing capacity, and residual volume showed 14%, 20%, and 21% abnormalities, respectively.
    • The single-breath N2 closing volume test (Phase IV/VC and Phase III slope) identified the most subtle changes, with 32% abnormalities in smokers with normal conventional spirometry.

    Conclusions:

    • The single-breath N2 closing volume test is superior to conventional spirometry and other tested indices for detecting early, subtle lung function abnormalities in smokers.
    • Phase IV/vital capacity was more sensitive in young/light smokers, while Phase III slope changes were more prevalent in older/heavier smokers.
    • The single-breath N2 closing volume test provides the highest yield of abnormal results, even when other indices are also impaired.