Related Experiment Videos
Pediatric renal transplantation--Indian experience
K Phadke1, S Ballal, K Venkatesh
1Department of Pediatrics, Manipal Hospital, Bangalore.
Indian Pediatrics
|August 26, 1998
Summary
Pediatric renal transplantation in India is a viable option for end-stage renal disease (ESRD). This study found acceptable graft survival rates and successful patient rehabilitation, demonstrating its global comparability.
Area of Science:
- Pediatric Nephrology
- Transplantation Surgery
- Immunology
Background:
- End-stage renal disease (ESRD) in children presents significant challenges.
- Renal transplantation is a critical treatment option for pediatric ESRD.
- Limited data exists on pediatric renal transplantation outcomes in India.
Purpose of the Study:
- To analyze the experience and outcomes of renal transplantation in children with ESRD in India.
- To evaluate graft survival and patient rehabilitation post-transplantation.
- To assess the feasibility of pediatric renal transplantation in a developing country context.
Main Methods:
- Retrospective study of 27 pediatric renal transplants performed over 7.5 years.
- Patients were categorized by age (<6 years and 6-12 years) and underlying renal disease (glomerular vs. tubulointerstitial).
- Surgical approaches (transperitoneal/extraperitoneal) and triple immunosuppression (Cyclosporine, Azathioprine, Steroids) were detailed.
Main Results:
- Follow-up ranged from 6 months to 7.5 years (mean 3.7 years).
- Graft survival rates were 73.2% at one year and 71% at two years.
- Ten episodes of acute rejection occurred, with three refractory cases; no surgical complications were reported.
Conclusions:
- Renal transplantation in Indian children with ESRD is an acceptable treatment modality.
- The study demonstrates comparable outcomes to global standards.
- Successful transplantation leads to satisfactory patient rehabilitation.