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The Splendore-Hoeppli phenomenon in hepatic botryomycosis
D Schlossberg1, M Pandey, R Reddy
1Department of Medicine, Episcopal Hospital, Philadelphia, Pennsylvania 19125, USA.
Journal of Clinical Pathology
|August 26, 1998
Summary
A 68-year-old diabetic man developed Streptococcus intermedius septicaemia and liver abscesses. This case highlights streptococcal botryomycosis, a rare infection associated with immunosuppression like diabetes mellitus.
Area of Science:
- Infectious Diseases
- Microbiology
- Immunology
Background:
- Botryomycosis is a rare, chronic bacterial infection.
- Streptococcus intermedius is a known pathogen, particularly in immunocompromised individuals.
- Diabetes mellitus is a common condition associated with increased infection risk.
Observation:
- A 68-year-old male patient with diabetes mellitus presented with septicaemia.
- Multiple liver abscesses were identified as the primary manifestation.
- Liver biopsy confirmed Streptococcus intermedius as the causative agent.
Findings:
- The liver biopsy revealed botryomycosis, characterized by granulomatous inflammation and bacterial colonies.
- The Splendore-Hoeppli phenomenon was observed, indicating a specific host-parasite interaction.
- This presentation underscores the link between diabetes mellitus and opportunistic infections.
Implications:
- This case emphasizes the importance of considering rare bacterial infections like botryomycosis in diabetic patients with severe infections.
- Early diagnosis and appropriate antibiotic therapy are crucial for managing Streptococcus intermedius infections.
- Further research into the pathogenesis of botryomycosis in immunocompromised states may improve patient outcomes.