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Novel spironucleosides: 1",3"-thiazolidine-2"-spiro-3'-3'-deoxyuridine derivatives
J M Tronchet1, I Kovács, F Barbalat-Rey
1Department of Pharmaceutical Chemistry, Sciences II, University of Geneva, Switzerland.
Nucleosides & Nucleotides
|August 26, 1998
Abstract:
Reaction of 2',5'-di-O-TBDMS-3'-ketouridine 1 with L-cysteine yielded in good yield a resolvable mixture of the two expected epimeric spironucleosides 2 and 3. Amidification of their carboxylic group took place readily and the ribo carboxamide 4 was oxidized to the corresponding sulfoxide 6. Despite their similarity to TSAO derivatives these compounds did not exhibit usable anti-HIV activity.