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Structural characterization of a DNA duplex modeled on a DNA:RNA hybrid of the polypurine tract recognized by a
M Kanagawa1, Y Okada, S Uesugi
1Department of Bioengineering, Faculty of Engineering, Yokohama National University, Japan.
Nucleosides & Nucleotides
|August 26, 1998
Abstract:
The structure of d(TTAAAAGAAAAGGG):d(CCCTTTTCTTTTAA) has been characterized by NMR. The minor grooves of the two dA-tracts are suggested to be rather narrow, and the portion linking the two dA tracts exhibits a slightly deviated structure from a standard B DNA, in order to maintain the narrowness of the minor groove. The structure of the dG-tract is also slightly deviated. Additionally, specific broadening of resonances is observed for the residues at or near the junction between the dA-tract and the dG-tract, suggesting local structural polymorphology.