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Stabilization of deoxyadenosine/polynucleotide complexes by 3',5'-di-O-benzoyl substituents
S K Chaturvedi1, R L Letsinger
1Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Nucleosides & Nucleotides
|August 26, 1998
Abstract:
3',5'-Di-O-benzoyldeoxyadenosine forms stable dT:dA:dT type complexes with poly(dT) and an oligo(dT)-cholesteryl conjugate in dilute aqueous solution. The benzoyl groups play an essential role in stabilizing these "triple stranded" complexes.