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[Post-parathyroidectomy pseudogout in primary hyperparathyroidism]

M A Gantes Mora1, B Rodríguez Lozano, E Trujillo Martín

  • 1Servicio de Reumatología, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, La Laguna, Santa Cruz de Tenerife.

Anales De Medicina Interna (Madrid, Spain : 1984)
|August 26, 1998
PubMed
Summary

Two cases of pseudogout occurred within 48 hours after parathyroidectomy for primary hyperparathyroidism. Prophylactic colchicine and preoperative screening for chondrocalcinosis are recommended to prevent this postoperative complication.

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Area of Science:

  • Endocrinology
  • Rheumatology
  • Surgical Oncology

Background:

  • Primary hyperparathyroidism is a condition requiring surgical intervention, often parathyroidectomy.
  • Pseudogout (calcium pyrophosphate dihydrate crystal deposition disease) can manifest acutely.
  • Chondrocalcinosis, the hallmark of pseudogout, may be asymptomatic and undiagnosed preoperatively.

Observation:

  • Two patients developed pseudogout within 48 hours following parathyroid adenoma resection.
  • Acute attacks were managed with calcium supplements, NSAIDs, and colchicine.
  • These cases highlight a potential, albeit rare, complication of parathyroid surgery.

Findings:

  • Postparathyroidectomy pseudogout is a recognized, though infrequent, complication.
  • Early diagnosis and management are crucial for symptom resolution.

Related Experiment Videos

  • Preoperative screening for chondrocalcinosis may identify at-risk individuals.

    • Implications:

    • Consider screening for chondrocalcinosis in patients undergoing parathyroidectomy.
    • Prophylactic low-dose oral colchicine (1 mg/day) may prevent postoperative pseudogout.
    • Further research is warranted to elucidate the pathophysiology and optimal prevention strategies.