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Risks of menopausal androgen supplementation
1Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912, USA.
Seminars in Reproductive Endocrinology
|August 26, 1998
Summary
Menopausal androgen replacement therapy (MART) may offer symptom relief but carries risks. Focus on dose and preparation to mitigate side effects like acne and hirsutism, ensuring safe testosterone levels.
Area of Science:
- Endocrinology
- Gynecology
- Pharmacology
Background:
- Increasing interest in menopausal androgen replacement therapy (MART) for symptom management.
- Efficacy compared to traditional hormone replacement therapy (HRT) is debated.
- Focus on potential side effects of MART is crucial.
Purpose of the Study:
- To review the side effects associated with menopausal androgen replacement therapy (MART).
- To evaluate the influence of dose, alkylation, and administration route on MART side effects.
- To assess the safety profile of MART in menopausal women.
Main Methods:
- Review of existing literature on MART side effects.
- Analysis of factors influencing androgen side effect profiles.
- Evaluation of reported incidences of virilizing and cutaneous effects.
Main Results:
- Alkylated androgens pose hepatic risks, though low doses in women may mitigate this.
- Virilizing effects (acne, hirsutism, voice deepening, clitoromegaly) are primary concerns.
- Endometrial hyperplasia risk with concurrent estrogen use is preventable with progestins.
Conclusions:
- MART safety is acceptable when supraphysiologic testosterone levels are avoided.
- Careful selection of MART preparation and dosage is essential.
- Ongoing research into long-term safety, including breast cancer risk, is warranted.