Related Experiment Videos
The macrophage-induced gene mig as a marker for clinical pathogenicity and in vitro virulence of Mycobacterium avium
M Meyer1, P W von Grünberg, T Knoop
1Institut für Medizinische Mikrobiologie und Hygiene, Universität zu Köln, D-50935 Cologne, Germany.
Infection and Immunity
|August 26, 1998
Abstract:
The capacity of 20 Mycobacterium avium complex isolates to multiply intracellularly in human monocyte-derived macrophages was assessed and correlated to the clinical relevance of each isolate and its reactivity with several candidate genetic virulence markers. The strongest correlation with a virulence phenotype was found for a conserved coding sequence of the macrophage-induced gene mig identified by a specific mig restriction fragment length polymorphism type.