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A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection
D M Williams1, B G Grubbs, T Darville
1Division of Infectious Diseases, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas 78284, USA. dwight.williams@med
Infection and Immunity
|August 26, 1998
Abstract:
Interleukin-6-deficient (IL-6(-/-)) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6(-/-) mice. IL-6 is needed for an optimal early host response to this infection.