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Related Experiment Videos

Retinoblastoma associated orbital cellulitis

P B Mullaney1, Z A Karcioglu, A M Huaman

  • 1King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.

The British Journal of Ophthalmology
|August 26, 1998
PubMed
Summary

Orbital cellulitis in retinoblastoma patients (4.8%) often indicates advanced intraocular tumors, not extraocular spread. Steroid treatment effectively reduced inflammation, aiding examination and enucleation for these rare cases.

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Area of Science:

  • Ophthalmology
  • Pediatric Oncology

Background:

  • Preseptal and orbital cellulitis are rare presenting features of intraocular retinoblastoma.
  • Understanding the association between cellulitis and retinoblastoma is crucial for diagnosis and management.

Purpose of the Study:

  • To determine the frequency of retinoblastoma associated cellulitis.
  • To review the clinical and histopathological features of retinoblastoma with cellulitis.

Main Methods:

  • Retrospective review of 292 retinoblastoma patients' medical records.
  • Inclusion of patients with cellulitis, excluding those with definite extraocular tumor extension.
  • Assessment of clinical, radiological, and histopathological variables.

Main Results:

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  • 14 patients (4.8%) presented with retinoblastoma associated cellulitis, mostly with advanced intraocular tumors (80-100% globe occupancy).
  • Cultures were negative; 10 patients responded to intravenous steroids.
  • Histopathology revealed large necrotic tumors with uveal and optic nerve involvement in enucleated eyes.

Conclusions:

  • Cellulitis in retinoblastoma often signifies advanced intraocular disease rather than orbital extension.
  • Periocular inflammation can hinder radiological assessment of scleral integrity.
  • Intravenous steroids effectively reduced inflammation, facilitating further management.