Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ketoconazole-induced liver damage

J A Findor1, J A Sorda, E B Igartua

  • 1División de Gastroenterología, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

Medicina
|August 26, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Necrotizing toxic laryngitis following combined polysubstance smoking of crack cocaine and heroin.

European annals of otorhinolaryngology, head and neck diseases·2026
Same author

When routine turns rare: Massive hematemesis unveiling hypopharyngeal perforation caused by a redon suction drain.

European annals of otorhinolaryngology, head and neck diseases·2026
Same author

Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors.

Pathology, research and practice·2019
Same author

Tissue alkalosis in cold-ischemia time.

Scientific reports·2017
Same author

Plasmablastic lymphoma involving the stomach in an HIV positive man.

Cytopathology : official journal of the British Society for Clinical Cytology·2016
Same author

Impact of the endoscopic teaching process on colonic adenoma detection.

Revista de gastroenterologia de Mexico·2014
Same journal

Detection of VIM-3 in oral squamous cell carcinomas: methodological limitations.

Medicina·2026
Same journal

The importance of specific antibodies in VIM-3 research: addressing a key methodological flaw.

Medicina·2026
Same journal

[From the right to be cared for to the duty to care: Legal bases for the implementation of palliative care in Argentina].

Medicina·2026
Same journal

[Surrogacy].

Medicina·2026
Same journal

[The misunderstandings in interpreting the "diagnostic superiority of Artificial Intelligence" and the explainable Artificial Intelligence].

Medicina·2026
Same journal

[Artificial intelligence in medicine: between algorithmic opacity and clinical responsibility].

Medicina·2026
See all related articles

Ketoconazole can cause severe liver damage, leading to fatalities in some cases. Regular monitoring is crucial to detect early signs of hepatotoxicity during antifungal therapy.

Area of Science:

  • Pharmacology
  • Hepatology
  • Mycology

Background:

  • Ketoconazole is a widely used antifungal medication.
  • Liver damage (hepatotoxicity) is a known, albeit rare, adverse effect of ketoconazole.
  • This study examines clinical cases of ketoconazole-induced liver injury.

Observation:

  • Five patients (4 female, 1 male) developed liver damage while on ketoconazole (400 mg/day) for mycoses.
  • Hepatotoxicity signs appeared around four weeks into therapy in female patients.
  • Two patients experienced fatal outcomes, one with fulminant liver failure and massive necrosis, the other with submassive necrosis.

Findings:

  • Cholestasis was a significant finding in four out of five cases.
  • Biochemical markers of biliary stasis persisted for months in surviving patients.

Related Experiment Videos

  • Continued ketoconazole use despite adverse effects was noted in fatal cases.

    • Implications:

    • Early and repeated monitoring for liver function is essential during ketoconazole treatment.
    • Healthcare providers should be vigilant for signs of hepatotoxicity.
    • Risk-benefit assessment is critical, especially in prolonged ketoconazole therapy.