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[Chronic urticaria: some clinico-immunological aspects]
M P Olivares Elegin1, L A Fernández, A Gómez Echevarría
1Hospital CQ Hermanos Ameijeiras, La Habana, Cuba.
Insights
Chronic urticaria and angioedema are common but poorly understood conditions. This study found elevated immunoglobulin E (IgE) in 70% of patients, suggesting an allergic component in chronic urticaria.
Area of Science:
- Immunology
- Dermatology
- Allergology
Context:
- Chronic urticaria and angioedema affect broad populations.
- Etiology of these conditions remains largely unknown.
- Investigating potential immunological markers is crucial.
Purpose:
- To investigate immunological markers in patients with chronic urticaria.
- To compare findings with a healthy control group.
- To explore the role of IgE, immunoglobulins, and immunocomplexes.
Summary:
- Fifty adult chronic urticaria patients and 26 healthy controls were studied.
- Elevated serum IgE was observed in 70% of patients.
- IgA, IgG, IgM levels were normal in most, and immunocomplexes were negative in 88%.
Impact:
- Findings suggest a potential role for elevated IgE in chronic urticaria pathogenesis.
- Further research can elucidate specific triggers and mechanisms.
- This study contributes to understanding the immunological basis of chronic urticaria.
Aims:
The chronic urticaria and the angioedema affect to the population's wide sectors and up to now their cause is ignored.
Material And Method:
They were studied during one year 50 mature patients with chronic urticaria coming from the ambulatory consultation of the service of alergología of the Hospital CQ Hermanos Ameijeiras. The diagnosis of chronic urticaria settled down clinically for observation of the lesions and for the time of its evolution that should exceed six weeks. It was included as group witness to 26 healthy individuals.
Results:
They were high levels for the IgE seric in the patients' 70%; you even normal of IgA, IgG and IgM in the great majority of the cases. The determination of circulating immunocomplexs gave negative in 88% of the sick and only positive in 12%. The tests for cutirreacción with extracts alergénicos micóticos, in reading at the 48 hours, were not negative in a significant way, among the group of sick and in the group witness.