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[Possibilities of drug prophylaxis of adrenalin-induced glaucoma (an experimental study)]
Abstract:
Experiments were carried out on 30 rabbits with adrenalin glaucoma. In 10 rabbits, intravenous adrenalin was paralleled by subconjunctival antioxidant superoxide dismutase (Erysod). Increase of intraocular pressure, changes of tonographic values, accumulation of lipid peroxidation products and alteration of the drainage zone morphology were observed in animals with adrenalin glaucoma. In animals administered erysod in parallel with adrenalin, tonometric and tonographic parameters were normal. The concentration of lipid peroxidation products in the blood was virtually normal in this group. Morphological studies showed no essential differences in the structure of the anterior chamber corner in the eyes of animals treated with erysod and in intact controls. The results demonstrate the possibility of preventing the development of primary open-angle glaucoma with erysod.
Insights
Superoxide dismutase (Erysod) prevented glaucoma development in rabbits. This antioxidant treatment normalized intraocular pressure and drainage zone morphology, suggesting a potential therapy for primary open-angle glaucoma.
Area of Science:
- Ophthalmology
- Pharmacology
- Biochemistry
Background:
- Adrenaline-induced glaucoma in rabbits mimics human primary open-angle glaucoma.
- Glaucoma is characterized by increased intraocular pressure and damage to the optic nerve.
- Oxidative stress and lipid peroxidation are implicated in glaucoma pathogenesis.
Purpose of the Study:
- To investigate the protective effects of superoxide dismutase (Erysod) against adrenaline-induced glaucoma in a rabbit model.
- To evaluate the impact of Erysod on intraocular pressure, ocular hemodynamics, and oxidative stress markers.
Main Methods:
- Glaucoma was induced in rabbits using intravenous adrenaline.
- Subconjunctival administration of superoxide dismutase (Erysod) was performed in parallel with adrenaline.
- Intraocular pressure, tonographic values, lipid peroxidation products, and anterior chamber morphology were assessed.
Main Results:
- Adrenaline-induced glaucoma led to increased intraocular pressure, altered tonography, elevated lipid peroxidation, and drainage zone damage.
- Concurrent administration of Erysod with adrenaline normalized tonometric and tonographic parameters.
- Erysod treatment maintained normal blood lipid peroxidation levels and prevented morphological alterations in the drainage zone.
Conclusions:
- Superoxide dismutase (Erysod) effectively prevents the development of glaucoma induced by adrenaline in rabbits.
- Erysod demonstrates potential as a therapeutic agent for preventing primary open-angle glaucoma by mitigating oxidative stress and preserving ocular structures.