DNA affinity of active alkaloids from Arisarum vulgare Targ

Some 2-alkylpyrrolidine and 2-alkylpiperidine alkaloids isolated from Arisarum vulgare Targ. demonstrated activity in a high-performance liquid chromatographic system designed to detect compounds capable of interacting with DNA. (-)-R-Bgugaine (N-H), an alkaloid prepared by synthesis, exhibited an important positive response, with total inhibition of DNA absorption at 254 nm. The concentration-dependence of these compounds was determined.