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Updated: Aug 6, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Generalized lymphangiomatosis with chylothorax and skin lymphangiomas in a neonate

P Dutheil1, J Leraillez, J Guillemette

  • 1Consultation de Dermatologie, Hôpital Saint-Vincent de Paul, Paris, France.

Pediatric Dermatology
|August 28, 1998
PubMed

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...