Ocimum sanctum leaf extract in the regulation of thyroid function in the male mouse

The effects of Ocimum sanctum leaf extract on the changes in the concentrations of serum triiodothyronine (T3), thyroxine (T4) and serum cholesterol; in the activities of hepatic glucose-6-phosphatase (G-6-P), superoxide dismutase (SOD) and catalase (CAT); hepatic lipid peroxidation (LPO) and on the changes in the weight of the sex organs were investigated. While the plant extract at the dose of 0.5 g kg-1 body wt. for 15 days significantly decreased serum T4 concentrations, hepatic LPO and G-6-P activity, the activities of endogenous antioxidant enzymes, SOD and CAT were increased by the drug. However, no marked changes were observed in serum T3 level, T3/T4 ratio and in the concentration of serum cholesterol. It appears that Ocimum sanctum leaf extract is antithyroidic as well as antioxidative in nature.