Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Threshold models in radiation carcinogenesis

D G Hoel1, P Li

  • 1Department of Biometry and Epidemiology, School of Medicine, Medical University of South Carolina, Charleston 29425, USA.

Health Physics
|August 29, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New models for evaluation of radiation-induced lifetime cancer risk and its uncertainty employed in the UNSCEAR 2006 report.

Radiation research·2008
Same author

Meta-analysis of standardized incidence and mortality rates of childhood leukaemia in proximity to nuclear facilities.

European journal of cancer care·2007
Same author

Residential mobility and risk of childhood acute lymphoblastic leukaemia: an ecological study.

British journal of cancer·2007
Same author

Relative toxicity of chronic irradiation by 45Ca beta particles and 242Cm alpha particles with respect to the production of lung tumors in CBA/Ca mice.

Radiation research·2006
Same author

Residential radon exposure and lung cancer risk: commentary on Cohen's county-based study.

Health physics·2004
Same author

Stable chromosome aberrations and ionizing radiation in airline pilots.

Aviation, space, and environmental medicine·2003
Same journal

Assessment of Health Risks of Adults and Children Due to Consumption of Uranium in Groundwater from Chengalpattu District, Tamil Nadu, India.

Health physics·2026
Same journal

Radiation Protection Abstracts, Volume 46, Number 1.

Health physics·2026
Same journal

Specialized Radiological Assets for Navigable Two-dimensional and Three-dimensional Virtual and Augmented Reality.

Health physics·2026
Same journal

DoseBusters: A Fully Immersive Virtual Reality Game for Radiation Protection and Detection.

Health physics·2026
Same journal

Radioactivity in Bottled Drinking Water from Greater Dhaka City and Concomitant Ingestion Doses to Consumers.

Health physics·2026
Same journal

Assessment of Radiation Dose and Protection Practices in Neonatal Radiography in NICUs.

Health physics·2026
See all related articles

This study on atomic bomb survivors suggests cancer incidence aligns with a threshold dose response, not purely linear models. Mortality data also showed improved fits with threshold models for leukemia.

Area of Science:

  • Radiation Epidemiology
  • Cancer Research
  • Biostatistics

Background:

  • Atomic bomb survivor data is crucial for understanding radiation's long-term health effects, particularly cancer.
  • Previous analyses often assumed linear dose-response relationships for radiation-induced cancers.

Purpose of the Study:

  • To analyze atomic bomb survivor data for evidence of a threshold dose-response relationship in cancer incidence and mortality.
  • To compare linear, linear-quadratic, and threshold dose-response models for radiation effects.

Main Methods:

  • Fitted established dose-response models to cancer incidence and mortality data from the atomic bomb survivors cohort.
  • Introduced threshold parameters into dose-response models to assess non-linear effects at low doses.
  • Evaluated model fits for solid tumors and various leukemia types (ALL, AML, CML).

Related Experiment Videos

Main Results:

  • Cancer incidence models with a threshold over-predicted low-dose exposures, suggesting non-linear or threshold effects.
  • Threshold models provided a better fit for cancer incidence compared to purely linear models, though statistical equivalence exists.
  • Threshold terms significantly improved model fits for both incidence and mortality of total leukemias and specific subtypes.

Conclusions:

  • Atomic bomb survivor cancer incidence data are more consistent with threshold or non-linear dose-response models than purely linear ones.
  • The inclusion of a threshold significantly enhances the fit of radiation dose-response models for leukemia (total and subtypes).
  • Findings highlight the importance of considering non-linear dose-response relationships in radiation risk assessment.