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Case study: fatal poisoning by malathion

T S Thompson1, R G Treble, A Magliocco

  • 1Saskatchewan Health, Provincial Laboratory, Regina, Canada.

Forensic Science International
|September 2, 1998
PubMed
Summary
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A fatal malathion poisoning case highlights its detection in post-mortem blood and gastric contents. Gas chromatography-mass spectrometry confirmed malathion, aiding toxicological analysis in fatal poisonings.

Area of Science:

  • Toxicology
  • Forensic Science
  • Analytical Chemistry

Background:

  • Malathion is an organophosphate insecticide widely used for pest control.
  • Intentional self-poisoning with pesticides is a significant global health concern.
  • Accurate post-mortem detection of insecticides is crucial for forensic investigations.

Observation:

  • A case of fatal poisoning (suicide) involving malathion was investigated.
  • Intact malathion was identified in post-mortem blood and gastric samples.
  • Malathion was quantified at 1.8 µg/ml in blood and 978 µg/ml in gastric contents.

Findings:

  • No malathion was detected in the autopsied liver tissue.
  • Gas chromatography-mass spectrometry (GC-MS) confirmed the presence and concentration of malathion.

Related Experiment Videos

  • The distribution of malathion varied significantly between different post-mortem matrices.

    • Implications:

    • This case demonstrates the utility of GC-MS for detecting and quantifying malathion in post-mortem specimens.
    • Findings underscore the importance of analyzing multiple biological samples in suspected pesticide poisoning cases.
    • Understanding malathion's post-mortem distribution aids in interpreting toxicological results for forensic and clinical purposes.