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Does inhaled pollen enter the sinus cavities?

T N Adkins1, H M Goodgold, L Hendershott

  • 1Department of Internal Medicine, Saint Louis University Health Sciences Center, Missouri, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|September 2, 1998
PubMed
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Inhaled ragweed pollen does not reach the paranasal sinuses, even in large doses. This suggests that allergic reactions in sinus tissues are unlikely to be triggered by inhaled allergens.

Area of Science:

  • Immunology
  • Otolaryngology
  • Allergy Research

Background:

  • Sinusitis is more common in allergic rhinitis patients.
  • The role of allergic processes within sinus tissues remains unclear.

Purpose of the Study:

  • To investigate if inhaled pollen can reach the sinus mucosa.

Main Methods:

  • Non-atopic adults inhaled Technetium-99m (Tc99m) labeled ragweed pollen.
  • Sinus imaging was performed using a tomographic rotating gamma camera.
  • Cadaver sinus and nasal cavity scans determined the technique's sensitivity.

Main Results:

  • The imaging technique could distinguish between nasal cavity and maxillary sinus.
  • A minimum of 20 microcuries (microci) of Tc99m was detectable in the sinuses.

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  • Despite inhaling a supraphysiologic dose of Tc99m-pollen, scans showed no detectable pollen in the paranasal sinuses of subjects.

    • Conclusions:

    • Inhaled ragweed pollen does not appear to penetrate the paranasal sinuses.
    • The likelihood of inhaled antigen-IgE antibody reactions occurring in the sinus mucosa is low.