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Helicobacter pylori eradication ameliorates primary Raynaud's phenomenon
A Gasbarrini1, I Massari, M Serricchio
1Internal Medicine Department, Catholic University, Rome, Italy.
Digestive Diseases and Sciences
|September 2, 1998
Summary
Eradicating Helicobacter pylori infection significantly reduces Raynaud
Area of Science:
- Vascular Medicine
- Infectious Diseases
- Gastroenterology
Background:
- Raynaud's phenomenon involves intermittent vasospasm in distal limbs.
- Helicobacter pylori infection is a potential, recently identified association.
- Understanding this link may offer new treatment avenues.
Purpose of the Study:
- To evaluate the impact of H. pylori eradication on Raynaud's attacks.
- To determine if treating H. pylori infection alleviates Raynaud's symptoms.
- To explore the pathogenetic link between H. pylori and Raynaud's phenomenon.
Main Methods:
- Forty-six patients with primary Raynaud's phenomenon were assessed.
- H. pylori infection diagnosed using the [13C]urea breath test.
- Eradication therapy administered for seven days to infected patients.
Main Results:
- H. pylori was eradicated in 83% of infected patients.
- Complete disappearance of Raynaud's attacks occurred in 17% post-eradication.
- Significant symptom reduction (discomfort, duration, frequency) observed in 72% of patients.
Conclusions:
- H. pylori eradication significantly decreases clinical Raynaud's attacks.
- Potential mechanism involves reduced vasoactive substances post-eradication.
- This suggests H. pylori as a treatable factor in some Raynaud's cases.