Related Experiment Videos
Granulomatous hepatitis: a retrospective study
B D Sabharwal1, N Malhotra, R Garg
1Department of Pathology, Dayanand Medical College, Ludhiana, Punjab.
Indian Journal of Pathology & Microbiology
|October 1, 1995
Summary
Tuberculosis is the most frequent cause of granulomatous hepatitis, a liver condition diagnosed in 51 out of 1234 biopsies. Other causes are rare, with some cases remaining undiagnosed.
Area of Science:
- Hepatology
- Infectious Diseases
- Pathology
Background:
- Granulomatous hepatitis is a liver inflammation characterized by granulomas.
- Identifying the underlying cause is crucial for effective treatment.
Purpose of the Study:
- To determine the etiological spectrum and clinical presentation of granulomatous hepatitis in a large cohort.
- To analyze the diagnostic yield of liver biopsies for granulomatous hepatitis.
Main Methods:
- Retrospective analysis of 1234 liver biopsies performed over a 10-year period.
- Identification and categorization of cases diagnosed with granulomatous hepatitis.
- Review of clinical, laboratory, and histopathological data.
Main Results:
- 51 cases (4.1%) of granulomatous hepatitis were identified.
- Tuberculosis was the leading cause, accounting for 55% of cases.
- Other identified causes included leprosy, sarcoidosis, histoplasmosis, brucellosis, amoebic liver abscess, lymphoma, and malignant granuloma.
- 12% of cases were undiagnosed, and 6% presented as fever of unknown origin (FUO).
- Common clinical findings were pyrexia and hepatosplenomegaly; jaundice was infrequent.
- Laboratory findings included elevated alkaline phosphatase, anemia, and elevated ESR.
Conclusions:
- Tuberculosis is the predominant cause of granulomatous hepatitis in this region.
- Liver biopsy remains a valuable tool for diagnosing granulomatous hepatitis and identifying its cause.
- A significant proportion of cases remain undiagnosed, highlighting the need for further diagnostic approaches.